INDUSTRIES
Unlocking The Power Of The Secretome
Accelerate your cell therapy to the patient
Scalable Solutions For Extracellular Vesicle Therapies
Beyond their cellular functions, mesenchymal stem cells (MSCs) and other therapeutic cell types exert powerful effects through their secretome, a complex mixture of cytokines, growth factors, and extracellular vesicles (EVs) that modulate immune responses, promote tissue repair, and influence regeneration. These cell-free products are emerging as next-generation biologics, offering therapeutic benefits without the risks associated with live cell transplantation.
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However, the composition and potency of the secretome are highly sensitive to culture conditions. Suspension systems often compromise EV yield and bioactivity due to shear stress and non-physiological environments. To preserve the therapeutic integrity of secreted products, adherent culture in a controlled environment is essential.
Our Solutions For Cell & Gene Therapies
Fixed-Bed Bioreactors
Our fixed-bed systems provide a stable, low-shear environment that supports adherent cell growth under physiologically relevant conditions. This setup preserves cell health and enhances the quality, consistency, and bioactivity of secreted factors and EVs, outperforming suspension systems in both yield and functional integrity.
Digitally Enhanced Bioprocess Optimization
Our digital toolbox enables simulation of bioprocess scenarios based on real experimental data. This allows us to model and compare multiple process configurations in silico, identify optimal operating windows, and predict outcomes before scaling up. Combined with real-time monitoring and data analytics, this approach ensures robust, reproducible, and GMP-aligned manufacturing workflows.
Scaled-Down Models For Rapid Optimization
Antleron uses miniaturized, representative bioreactor models to accelerate process development. These scaled-down systems allow for high-throughput testing of culture conditions, media compositions, and harvest strategies, reducing time and cost while ensuring scalability.
Antleron Services
We support developers of secretome- and EV-based therapies with:
Custom Process Development
Tailored protocols for adherent cell expansion and secretome harvesting in fixed-bed systems.
CRO Support
Smart scale-down model development and characterization, full biolab and analytical capabilities, simulation and modelling capabilities, manufacturing technology benchmarking and integration. Feasibility studies, assay development, and potency testing tailored to your therapeutic goals.
Regulatory Support
Guidance on CQA definition, comparability, and documentation for regulatory submissions.
Antleron Track Record
Antleron has enabled secretome and EV developers to:
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Transition from flask- or suspension-based systems to scalable fixed-bed platforms
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Improve EV yield, purity, and functional consistency
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Accelerate development timelines with robust, GMP-aligned processes
Our team combines deep biological insight with engineering expertise to deliver scalable, high-quality solutions for cell-free therapeutics.
