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INDUSTRIES

Mesenchymal Stem Cells

Accelerate your cell therapy to the patient

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Mesenchymal Stem Cells In Therapeutic Applications

Mesenchymal stem cells (MSCs) are a cornerstone of regenerative medicine due to their dual capacity for tissue repair and immunomodulation. Their ability to secrete bioactive factors, modulate immune responses, and differentiate into multiple lineages makes them highly versatile for treating inflammatory, degenerative, and autoimmune conditions.

 

However, translating MSCs into consistent, scalable, and regulatory-compliant therapies remains a major challenge, due to donor variability, senescence, phenotypic drift, and manufacturing bottlenecks.

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Antleron addresses these challenges by engineering robust MSC bioprocesses that preserve critical quality attributes (CQAs) from lab to clinic. Our fixed bed-based bioprocess, CellGuide®, allows to develop bespoke manufacturing strategies, targeted to the needs of your application.

Hybrid Cell Culture - Our solutions For Cell & Gene Therapies

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Fixed-Bed Bioreactors

Closed, scalable systems optimized for adherent MSC expansion with uniform nutrient distribution, low shear stress and improved harvestability. The increased number of conditions thanks to the scalable range (mL to L), fast-tracks development without skyrocketing costs.

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Digitally Enhanced Bioprocess Development

Increase your number of test conditions (you can run thousands of in-silico conditions!) and data through digitally conducted experiments to efficiently improve your bioprocess understanding, in turn allowing more robust optimization and control strategies, all at a fraction of the cost and time of typical bioprocess development runs. 

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Quality-By-Design

Data-driven process development aligned with regulatory expectations for critical quality attributes and comparability. 

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Antleron Services

Antleron offers tailored services to support MSC therapy developers at every stage:

  • Custom Process Development

From donor screening to scale-up, we co-develop optimized MSC expansion protocols.

  • CRO Support

Smart scale-down model development and characterization, full biolab and analytical capabilities, simulation and modelling capabilities, manufacturing technology benchmarking and integration. Feasibility studies, assay development, and potency testing tailored to your therapeutic goals.

  • Regulatory Support

Guidance on process mapping, CQA, PP and MA definition and impact, comparability studies, and documentation for IND/IMPD submissions.

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Antleron Track Record

With a proven track record in MSC bioprocessing, Antleron has successfully partnered with biotech companies, academic groups, and clinical developers to:

 

  • Increase MSC yield and consistency across donors and batches 

  • Translated 2D protocols into fixed-bed processes with improved productivity 

  • From cell to tissue – developing complex MSC-based bioprocesses in novel bioreactor systems.

 

Our multidisciplinary team combines deep MSC expertise with engineering innovation to deliver results that matter.

Reach out to us to explore how Antleron can answer your needs.

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Based on a first conversation, we will engage our team of experts to propose a solution tailored to your research, development and manufacturing challenges.

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