SOLUTIONS
Technology
3D printing, artificial intelligence and bioreactors at your disposal
Your Advanced Therapy Partner
Hybrid Cell Culture: Bridging Biology and Technology for Next-Generation Therapies
At Antleron, we design and develop hybrid bioprocess solutions to enable faster, more affordable, and more equitable delivery of cell and gene therapies to patients. Our mission is to merge biology with engineering and a Quality-by-Design-based methodology for process development, creating smart, modular, and scalable processes that accelerate innovation while ensuring quality, compliance, and sustainability.
​
Central to this approach is Antleron's hybrid bioprocess development platform, CellGuide®, a proprietary set of integrated tools that enable the development of bioprocesses optimized for scaling, economic viability, regulatory robustness, and environmental sustainability.
​
By adding NEXUS, Antleron’s digital platform which hosts your process models and custom applications in one secure, centralized environment, Antleron transforms traditional culture methods into adaptive, scalable, data-driven systems. The hybrid bioprocess development platform embraces the complexity and variability of living raw materials, cells, while addressing the personalized nature of advanced therapies.
​
This convergence of digital and biological technologies turns our Factory-of-the-Future vision into reality, enabling precise control, scalability, reproducible results, and flexible manufacturing environments that evolve with therapeutic needs.
Risk-Based Bioprocess Development
Our process development package is rooted in the Quality-by-Design methodology. QbD enables our team of multidisciplinary specialists to take all process aspects into consideration: quality, process, materials and Target Product Profile. Any QbD-enabled bioprocess we have developed, supports ATMP manufacturing upscaling.
​
We develop fully closed bioprocesses which can be monitored online. Automation is extremely useful especially since we measure parameters inline and steer the process without operator intervention. This increases bioprocess robustness and efficiency. The use of scaled models allow us to evaluate bioprocesses more extensively, flexibly and affordably. More complete bioprocess data sets allow for making solid science-based decisions and reducing the required number of costly full-scale experiments.
Fixed Bed Bioreactors
We develop unique bioreactors offering geometrically customized and controlled fixed bed structures, resulting in better cell distribution, and thus higher and more consistent product yields. We use a set of proprietary tools and methodologies to create fixed bed bioreactor solutions customized towards cell type, application and target system. These customized bioreactors are the core of Antleron's CellGuide® platform.
CellGuide® - Cell-Based Innovation From Concept To Solution
The Antleron CellGuide® platform is an integrated, scalable, and controlled innovation platform that accelerates the development of advanced therapy and bioprocess solutions. By uniting biology, engineering, and digital technologies, it provides a flexible, data-driven foundation for translating concepts into manufacturable, regulatory-compliant products.
​
Scalable fixed-bed configurations enable process exploration at relevant scales, supporting in-depth understanding while keeping cost and complexity under control.
​
CellGuide® combines in-silico modeling, microfluidic experimentation, custom process models tailored for your development needs and digitally enhanced data analytics to understand and control complex biological processes. This integrated approach enables faster development cycles, predictive process design, and consistent, high-quality outcomes.
​
Built for collaboration, CellGuide® aligns customer goals, partner technologies, and Antleron’s multidisciplinary expertise into tailored solutions that bring innovation from lab to life.
NEXUS - Digitally Enhanced, Data-Intelligent Bioprocess Development
A robust bioprocess consistently delivers high-quality products at the right scale and cost. To achieve this, Antleron’s NEXUS platform integrates closed-loop monitoring and automated control to enable real-time adaptation to the variability of living cells and the complexity of biological systems.
At the heart of NEXUS are digital twins, virtual representations built from experimental cell culture data and advanced soft-sensor models. These digital counterparts allow us to simulate, predict and optimize bioprocesses in silico, accelerating development, reducing costs, and deepening process understanding.
By embedding autonomous, self-adjusting operations, NEXUS transforms biological variability into predictable, optimized performance, laying the foundation for efficient, reliable, and scalable bioprocesses.
Antleron In Numbers
4
sensor modalities available: metabolic biosensing, oxygen, impedance and optical
250
unique fixed bed designs for your seed train and viral vector production
More than
1 000 000
cells per cm² in our fixed beds
